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Need For Speed Most Wanted 1.3 Black Edt. (ENG RUS) PC




gameAcute and chronic liver injury induced by di(2-ethylhexyl)phthalate in the female rat. Di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer, was evaluated for its hepatotoxicity in a dose-dependent manner. Although the oral LD50 for DEHP was lower than 0.2 g/kg, all rats died after a single gavage of 5 g/kg. The liver histopathological findings were consistent with pericentral necrosis. The activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also elevated in the animals given DEHP, and the increases were dose dependent. In addition, serum triglycerides (TG) were significantly increased after DEHP administration. The activities of serum alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (gamma-GTP), and lactate dehydrogenase (LDH) were decreased in DEHP-treated animals. Serum glutathione S-transferase (GST) was also decreased by DEHP treatment. Histopathological examination of the liver of DEHP-treated rats revealed mild focal granulomatous reactions. The increases in serum TG and GST activity in DEHP-treated rats were recovered by coadministration of cholic acid (CA). The results demonstrate that DEHP causes acute and chronic liver injury in female rats. This report suggests that DEHP is hepatotoxic in the female rat and that CA may prevent DEHP-induced hepatotoxicity in the female rat.Neuromuscular blockade, serum lactic acid and lactate clearance: effect of calcium and magnesium supplementation. Using a randomised, double-blind, cross-over study design, 20 healthy volunteers received 0.5 g of elemental calcium and 0.4 g of elemental magnesium with a drink or water placebo. A 3-h neuromuscular blockade was induced using a double-blinded, standardized technique. One hour after the last dose of the neuromuscular blocking agent, blood was taken from a catheter in the radial artery. The subjects then drank 10 ml of a suspension containing 10 mmol/l sodium lactate and 1 mmol/l calcium. Following a further 1 h of post-blockade recovery, blood was taken for determination of serum lactate and calcium. Samples of blood taken from the femoral vein for measurement




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Need For Speed Most Wanted 1.3 Black Edt. (ENG RUS) PC
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